The Karat iron deposit is located in the vicinity of Sangan mining district, in the Northeast of Iran. The basement rocks of the Karat area include hornfels, metamorphosed limestone, marble, sandstone, siltstone and red shale with interlayers of marl, shale and marl, thick-layered red conglomerate and alluvial deposits. The intrusion of a granite batholith in the sedimentary units of the Karat iron deposit has led to the formation of iron deposits in the margin of this batholith. The most important ore minerals include magnetite, hematite, goethite, limonite and a small amount of sulfide minerals such as pyrite and chalcopyrite. Geochemical data indicate a strong correlation between the Ni, Mg, and V to Fe in mineralization zone, which indicates the magmatic origin of the Karat iron deposit. In order to investigate the characteristics of the ore-forming Fluid of the skarn Karat iron deposit Fluid inclusions of quartz veins were analyzed. The results show that Fluids are mainly (L+V) type, low to medium salinity (4.48 to 16.42% NaCl) and the homogenization temperature of 200 to 390 degrees Celsius. Mineralogical, geochemical, and Fluid-inclusion data show that the magmatics, meteoric and metamorphic Fluids are responsible for Fe-mineralization in the skarn and Isothermal mixing and surface Fluid dilution are main evolution factors in mineralization Fluids. It seems that the main phase of mineralization has been occurred during the retrograde stage skarn.